Macro-scale topology optimization for controlling internal shear stress in a porous scaffold bioreactor
نویسندگان
چکیده
منابع مشابه
Macro-scale topology optimization for controlling internal shear stress in a porous scaffold bioreactor.
Shear stress is an important physical factor that regulates proliferation, migration, and morphogenesis. In particular, the homeostasis of blood vessels is dependent on shear stress. To mimic this process ex vivo, efforts have been made to seed scaffolds with vascular and other cell types in the presence of growth factors and under pulsatile flow conditions. However, the resulting bioreactors l...
متن کاملComputational evaluation of oxygen and shear stress distributions in 3D perfusion culture systems: macro-scale and micro-structured models.
We present a combined macro-scale/micro-scale computational approach to quantify oxygen transport and flow-mediated shear stress to human chondrocytes cultured in three-dimensional scaffolds in a perfusion bioreactor system. A macro-scale model was developed to assess the influence of the bioreactor design and to identify the proper boundary conditions for the micro-scale model. The micro-scale...
متن کاملA BINARY LEVEL SET METHOD FOR STRUCTURAL TOPOLOGY OPTIMIZATION
This paper proposes an effective algorithm based on the level set method (LSM) to solve shape and topology optimization problems. Since the conventional LSM has several limitations, a binary level set method (BLSM) is used instead. In the BLSM, the level set function can only take 1 and -1 values at convergence. Thus, it is related to phase-field methods. We don’t need to solve the Hamilton-Jac...
متن کاملTOPOLOGY OPTIMIZATION OF PERFORATED STEEL PLATE SHEAR WALLS WITH THICK PLATE IN SIMPLE FRAMES
In this paper, topology optimization (TO) is applied to determine the form, size and location of holes for the special form of perforated steel plate shear wall (PSPSW). The proposed model is based on the recently presented particular form of PSPSW that is called the ring-shaped steel plate shear wall. The strain energy is selected as the objective function in the optimization. Simple Isotropic...
متن کاملBioreactor Scale-up for Water-Gas Shift Reaction
A scale-up study has been performed with three different size reactors to establish the optimum operating conditions for the hydrogen production from synthesis gas by biological water-gas shift reaction using the photosynthetic bacterium Rhodosprilliunt rubrum. Optimum medium composition and operating conditions previously determined in a bench scale 1.25 L continuous stirred tank reactor (CSTR...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biotechnology and Bioengineering
سال: 2012
ISSN: 0006-3592
DOI: 10.1002/bit.24440